preheat oven to 400 degrees
Melt butter, then stir together with panko, and topping cheeses in a bowl until well combined.
melt butter in a heavy medium saucepan over medium-low heat and stir in flour. Cook roux, stirring, 3 minutes, then whisk in milk. Bring sauce to a boil, whisking constantly, then simmer, whisking occasionally for 3 minutes. Stir in cheeses, 2tsp. Salt and 1/2 tsp pepper until smooth. Remove from heat.
Cook macaroni in a pot of boiling salted water until al dente. Reserve 1 cup cooking water and drain macaroni in colander. stir together macron, reserved cooking water and sauce in a large bowl. Transfer to 2 buttered 2 quart shallow baking dishes.
Sprinkle topping evenly over macaroni and bake until golden and bubbling, 20-25 minutes.